Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats

Table 1 Selection of up regulated genes linked to neuronal plasticity

	Ipsi cx		Hippocampus		Contra cx
Gene title	Factor volu/control	Factor cast/control	Factor volu/control	Factor cast/control	Factor volu/control	Factor cast/control
Receptors/postsynaptic plasticity
Glutamate receptor, ionotropic, N-methyl D-aspartate 2A	2.16	2.63	2.66	2.69	2.41	2.31
Glutamate receptor, ionotropic, kainate 1	1.35	1.47	1.79	2.08	1.20	1.81
Glutamate receptor interacting protein 1	1.11	1.45	0.95	1.53	1.13	1.67
Neurotrophic tyrosine kinase, receptor, type 2	1.58	1.60	1.60	1.60	1.52	2.20
Homer homolog 1 (Drosophila)	1.39	2.07	1.36	1.87	1.33	2.16
Protein kinase C, zeta	1.92	1.54	1.52	1.12	1.32	1.11
Neuronal morphological plasticity
Dynein, axonemal, light chain 1	2.40	2.96	1.91	2.52	1.78	2.39
Neurexin 1	2.09	1.88	2.30	2.44	2.30	2.50
Microtubule-associated protein 1B	2.01	2.29	2.12	2.17	2.54	2.17
Microtubule-associated protein tau	1.82	1.84	1.79	1.79	1.87	1.89
Tenascin R	1.33	2.04	1.62	2.52	1.98
MAP/microtubule affinity-regulating kinase 3	1.76	1.61	1.32	1.23	1.44	2.45
Dynein cytoplasmic 1 light intermediate chain 1	1.27	1.14	1.78	1.53	1.34	1.29
Connectivity, pathfinding, plasticty
Slit homolog 2 (Drosophila)	1.95	2.13	1.75	1.87	2.02	2.05
Eph receptor B2	1.39	1.40	1.26	1.58	1.39	1.44
Eph receptor B3	0.96	1.33	1.48	2.10	1.09	1.62
EphA5	1.83	2.50	1.77	2.22	1.74	2.35
Ion channel
Sodium channel, voltage-gated, type III, beta	1.70	1.62	2.19	2.05	1.84	2.60
Presynapse
Synaptotagmin V	1.22	1.89	1.12	1.25	1.28	1.83
Syntaxin 8	1.47	1.20	1.60	1.33	1.38	1.33

Given are the gene names and mean regulation factors in the contrast “volu/control” (voluntary training) and “cast/control” (forced arm use).

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