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Figure 4 | Experimental & Translational Stroke Medicine

Figure 4

From: Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model

Figure 4

Quantitative assessment of ADC and T1 flair images show ischemia, edema and atrophy. ROI analysis was performed on ADC maps (A) with regions of 80% (B) and 40% (C) normal ADC being determined. Mean ADC value of normal control tissue of 755.00 ± 24.26 ×10−6 mm/s was significantly (*= significant difference at p< 0.05) higher than 80% and 40% ADC means of 525.43 ± 21.61 ×10−6 mm/s and 321.29 ± 2.83 ×10−6 mm/s respectively (D). T1 FLAIR ROI analysis showed an increase in right (stroked) cerebral volume at 24 hrs (*= significant difference at p< 0.05 within time point) with mean right and left (normal) cerebral volumes of 404.17 ± 8.73 cc and 358.50 ± 7.16 cc respectively (E). Between 24 hrs and 90 days, no significant difference was noted in the mean left cerebral volume (90d: 354.50 ± 1290 cc). The mean right cerebral volume at 90d, measuring 295.33 ± 20.07 cc was significantly (# = significant difference at p< 0.05 within brain hemisphere) decreased from left normal cerebral volume (354.50 ± 12.90 cc) at 90 days and the 24 hrs mean right cerebral volume (404.17 ± 8.73 cc). The volume of lost tissue (59.17 ± 10.06 cc), as quantified from the T1w-FLAIR was not significantly different from 80% ADC volume (103 ± 28.18 cc), while 40% ADC volume (11.50 ± 3.86) was significantly different (F;*= significant difference at p< 0.05).

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