Figure 4From: Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model Quantitative assessment of ADC and T1 flair images show ischemia, edema and atrophy. ROI analysis was performed on ADC maps (A) with regions of 80% (B) and 40% (C) normal ADC being determined. Mean ADC value of normal control tissue of 755.00 ± 24.26 ×10−6 mm/s was significantly (*= significant difference at p< 0.05) higher than 80% and 40% ADC means of 525.43 ± 21.61 ×10−6 mm/s and 321.29 ± 2.83 ×10−6 mm/s respectively (D). T1 FLAIR ROI analysis showed an increase in right (stroked) cerebral volume at 24 hrs (*= significant difference at p< 0.05 within time point) with mean right and left (normal) cerebral volumes of 404.17 ± 8.73 cc and 358.50 ± 7.16 cc respectively (E). Between 24 hrs and 90 days, no significant difference was noted in the mean left cerebral volume (90d: 354.50 ± 1290 cc). The mean right cerebral volume at 90d, measuring 295.33 ± 20.07 cc was significantly (# = significant difference at p< 0.05 within brain hemisphere) decreased from left normal cerebral volume (354.50 ± 12.90 cc) at 90 days and the 24 hrs mean right cerebral volume (404.17 ± 8.73 cc). The volume of lost tissue (59.17 ± 10.06 cc), as quantified from the T1w-FLAIR was not significantly different from 80% ADC volume (103 ± 28.18 cc), while 40% ADC volume (11.50 ± 3.86) was significantly different (F;*= significant difference at p< 0.05).Back to article page