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Figure 2 | Experimental & Translational Stroke Medicine

Figure 2

From: Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke

Figure 2

Enhancement of autophagy with rapamycin decreases infarct size in MCAL mouse models of ischemic stroke injury. A). 8–12 week old male C57BL/6 J mice underwent MCAL stroke injury, and were treated twice (0 and 24 hours) with either saline, rapamycin (rapa) to enhance autophagy, chloroquine (CQ) to inhibit autophagy, or a combination of rapa and CQ. Infarct size analysis using 2% TTC staining (n = 9 mice per group). B). Quantitation of panel A data (* = p < 0.05). Note tissue drop out in the lesion site is due to the fragility of the tissue, not surgical damage.

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