Figure 2From: Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke Enhancement of autophagy with rapamycin decreases infarct size in MCAL mouse models of ischemic stroke injury. A). 8–12 week old male C57BL/6 J mice underwent MCAL stroke injury, and were treated twice (0 and 24 hours) with either saline, rapamycin (rapa) to enhance autophagy, chloroquine (CQ) to inhibit autophagy, or a combination of rapa and CQ. Infarct size analysis using 2% TTC staining (n = 9 mice per group). B). Quantitation of panel A data (* = p < 0.05). Note tissue drop out in the lesion site is due to the fragility of the tissue, not surgical damage.Back to article page