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Experimental & Translational Stroke Medicine

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  1. Content type: Review

    Stroke is regularly accompanied by dysphagia and other factors associated with decreased nutritional intake. Dysphagia with aspiration pneumonia and insufficient nutritional intake lead to worse outcome after ...

    Authors: Rainer Wirth, Christine Smoliner, Martin Jäger, Tobias Warnecke, Andreas H Leischker and Rainer Dziewas

    Citation: Experimental & Translational Stroke Medicine 2013 5:14

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  2. Content type: Research

    The human population mostly affected by stroke is more than 65 years old. This study was designed to meet the recommendation that models of cerebral ischemia in aged animals are more relevant to the clinical s...

    Authors: Slavianka G Moyanova, Rumiana G Mitreva, Lidia V Kortenska, Ferdinando Nicoletti and Richard T Ngomba

    Citation: Experimental & Translational Stroke Medicine 2013 5:13

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  3. Content type: Short report

    Exogenous administration of the anti-inflammatory cytokine, interleukin 10 (IL-10), is known to promote neuroprotection and mitigate neuroinflammation after ischemia. However, endogenous expression and localiz...

    Authors: Abdelrahman Y Fouda, Anna Kozak, Ahmed Alhusban, Jeffrey A Switzer and Susan C Fagan

    Citation: Experimental & Translational Stroke Medicine 2013 5:12

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  4. Content type: Research

    Systemic thrombolysis with recombinant tissue plasminogen activator (rt-PA) is the standard of acute stroke care. Its potential to increase the risk of secondary intracerebral hemorrhage, especially if adminis...

    Authors: Aijia Cai, Frieder Schlunk, Ferdinand Bohmann, Sepide Kashefiolasl, Robert Brunkhorst, Christian Foerch and Waltraud Pfeilschifter

    Citation: Experimental & Translational Stroke Medicine 2013 5:11

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  5. Content type: Review

    Structural plasticity with synapse formation and elimination is a key component of memory capacity and may be critical for functional recovery after brain injury. Here we describe in detail two surgical techni...

    Authors: Christian Stetter, Markus Hirschberg, Bernhard Nieswandt, Ralf-Ingo Ernestus, Manfred Heckmann and Anna-Leena Sirén

    Citation: Experimental & Translational Stroke Medicine 2013 5:9

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  6. Content type: Short report

    Human cerebral small vessel disease (CSVD) has distinct histopathologic and imaging findings in its advanced stages. In spontaneously hypertensive stroke-prone rats (SHRSP), a well-established animal model of ...

    Authors: Stine Mencl, Cornelia Garz, Solveig Niklass, Holger Braun, Eva Göb, György Homola, Hans-Jochen Heinze, Klaus G Reymann, Christoph Kleinschnitz and Stefanie Schreiber

    Citation: Experimental & Translational Stroke Medicine 2013 5:8

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  7. Content type: Research

    To assess acute effects of bevacizumab (anti-VEGF therapy) on cerebral microvessels and systemic cardiovascular regulation.

    Authors: Manja Reimann, Gunnar Folprecht, Rocco Haase, Karolin Trautmann, Gerhard Ehninger, Heinz Reichmann, Focke Ziemssen and Tjalf Ziemssen

    Citation: Experimental & Translational Stroke Medicine 2013 5:7

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  8. Content type: Review

    This article reviews experimental and clinical data on the use of magnesium as a neuroprotective agent in various conditions of cerebral ischemia. Whereas magnesium has shown neuroprotective properties in anim...

    Authors: Thomas Westermaier, Christian Stetter, Ekkehard Kunze, Nadine Willner, Furat Raslan, Giles H Vince and Ralf-Ingo Ernestus

    Citation: Experimental & Translational Stroke Medicine 2013 5:6

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  9. Content type: Research

    N-Acetylcystein (NAC) reduces the reperfusion injury and infarct size in experimental macroangiopathic stroke. Here we now investigate the impact of NAC on the development of the histopathology of microangiopa...

    Authors: Celine Zoe Bueche, Cornelia Garz, Siegfried Kropf, Daniel Bittner, Wenjie Li, Michael Goertler, Hans-Jochen Heinze, Klaus Reymann, Holger Braun and Stefanie Schreiber

    Citation: Experimental & Translational Stroke Medicine 2013 5:5

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  10. Content type: Review

    Cerebral small vessel disease (CSVD, cerebral microangiopathy) leads to dementia and stroke-like symptoms. Lacunes, white matter lesions (WML) and microbleeds are the main pathological correlates depicted in i...

    Authors: Stefanie Schreiber, Celine Zoe Bueche, Cornelia Garz and Holger Braun

    Citation: Experimental & Translational Stroke Medicine 2013 5:4

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  11. Content type: Review

    Many survivors of stroke experience arm impairments, which can severely impact their quality of life. Forcing use of the impaired arm appears to improve functional recovery in post-stroke hemiplegic patients, ...

    Authors: Jessica M Livingston-Thomas and R Andrew Tasker

    Citation: Experimental & Translational Stroke Medicine 2013 5:2

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  12. Content type: Research

    Previous reports assessing the neuroprotective role of nonselective Nitric Oxide synthase (NOS) inhibitor N-nitro-L-arginine-methylester (L-NAME) following cerebral ischemia/reperfusion are contradictory. The ...

    Authors: Hiba A Awooda, Mohamed F Lutfi, Gihan M Sharara and Amal M Saeed

    Citation: Experimental & Translational Stroke Medicine 2013 5:1

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  13. Content type: Research

    Stroke occurs more frequently in the elderly population and presents the number one leading cause of persistent disability worldwide. Lack of effective treatment to enhance brain repair and improve functional ...

    Authors: Chun-Shu Piao, Maria E Gonzalez-Toledo, Xi Gu and Li-Ru Zhao

    Citation: Experimental & Translational Stroke Medicine 2012 4:25

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  14. Content type: Short report

    Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia. Howev...

    Authors: Jan-Sören Padberg, Matijs Van Meurs, Jan T Kielstein, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Jan G Zijlstra, Csaba P Kovesdy and Philipp Kümpers

    Citation: Experimental & Translational Stroke Medicine 2012 4:24

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  15. Content type: Research

    Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerou...

    Authors: Furat Raslan, Christiane Albert-Weißenberger, Thomas Westermaier, Saker Saker, Christoph Kleinschnitz and Jin-Yul Lee

    Citation: Experimental & Translational Stroke Medicine 2012 4:23

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  16. Content type: Meeting report

    From November 2nd - 4th 2012, the 4th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Again more than 60 participants, predominantly at the doctoral student or postdoc level, gathered to share th...

    Authors: Ralf A Linker, Sven G Meuth, Tim Magnus, Thomas Korn and Christoph Kleinschnitz

    Citation: Experimental & Translational Stroke Medicine 2012 4:22

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  17. Content type: Review

    Ischemic stroke is a leading cause of morbidity and mortality worldwide. Elevated plasma aldosterone levels are an independent cardiovascular risk factor and are thought to contribute to hypertension, a major ...

    Authors: Quynh N Dinh, Thiruma V Arumugam, Morag J Young, Grant R Drummond, Christopher G Sobey and Sophocles Chrissobolis

    Citation: Experimental & Translational Stroke Medicine 2012 4:21

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  18. Content type: Short report

    The pathophysiology of sterile inflammation following focal ischemic stroke is complex and not fully understood, but there is growing evidence that it offers several therapeutic options beyond the hitherto exi...

    Authors: Karoline Möller, Tobias Stahl, Johannes Boltze and Daniel-Christoph Wagner

    Citation: Experimental & Translational Stroke Medicine 2012 4:20

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  19. Content type: Research

    Docosahexaenoic acid (DHA) complexed to human serum albumin (Alb) is neuroprotective after experimental stroke. Here we tested using lower concentrations of albumin as part of the complex to achieve neuroprote...

    Authors: Tiffany N Eady, Larissa Khoutorova, Kristal D Atkins, Nicolas G Bazan and Ludmila Belayev

    Citation: Experimental & Translational Stroke Medicine 2012 4:19

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  20. Content type: Research

    A new thromboembolic animal model showed beneficial effects of t-PA with an infarct volume reduction of 36.8% in swiss mice. Because knock-out animal experiments for stroke frequently used C57BL76 mice we eval...

    Authors: Friederike L Langhauser, Patrick M Heiler, Saskia Grudzenski, Andreas Lemke, Angelika Alonso, Lothar R Schad, Michael G Hennerici, Stephen Meairs and Marc Fatar

    Citation: Experimental & Translational Stroke Medicine 2012 4:18

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  21. Content type: Research

    Bone marrow-derived mononuclear cells (BM MNC) have been effectively used to treat experimental stroke. Most of the preclinical trials have been performed in young and healthy laboratory animals, even though a...

    Authors: Daniel-Christoph Wagner, Mitja Bojko, Myriam Peters, Marlene Lorenz, Cornelia Voigt, Alexander Kaminski, Dirk Hasenclever, Markus Scholz, Alexander Kranz, Gesa Weise and Johannes Boltze

    Citation: Experimental & Translational Stroke Medicine 2012 4:17

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  22. Content type: Research

    Intracerebral administration of the angiotensin II type 2 receptor (AT2R) agonist, CGP42112, is neuroprotective in a rat model of ischemic stroke. To explore further its possible cellular target(s) and therapeuti...

    Authors: Seyoung Lee, Vanessa H Brait, Thiruma V Arumugam, Megan A Evans, Hyun Ah Kim, Robert E Widdop, Grant R Drummond, Christopher G Sobey and Emma S Jones

    Citation: Experimental & Translational Stroke Medicine 2012 4:16

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  23. Content type: Research

    Neuroglobin is considered to be a novel important pharmacological target in combating stroke and neurodegenerative disorders, although the mechanism by which this protection is accomplished remains an enigma. ...

    Authors: Zindy Raida, Christian Ansgar Hundahl, Jesper Kelsen, Jens Randel Nyengaard and Anders Hay-Schmidt

    Citation: Experimental & Translational Stroke Medicine 2012 4:15

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    The Erratum to this article has been published in Experimental & Translational Stroke Medicine 2013 5:10

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