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  1. Review

    Guideline clinical nutrition in patients with stroke

    Stroke is regularly accompanied by dysphagia and other factors associated with decreased nutritional intake. Dysphagia with aspiration pneumonia and insufficient nutritional intake lead to worse outcome after ...

    Rainer Wirth, Christine Smoliner, Martin Jäger, Tobias Warnecke, Andreas H Leischker and Rainer Dziewas

    Experimental & Translational Stroke Medicine 2013 5:14

    Published on: 1 December 2013

  2. Research

    Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke

    The human population mostly affected by stroke is more than 65 years old. This study was designed to meet the recommendation that models of cerebral ischemia in aged animals are more relevant to the clinical s...

    Slavianka G Moyanova, Rumiana G Mitreva, Lidia V Kortenska, Ferdinando Nicoletti and Richard T Ngomba

    Experimental & Translational Stroke Medicine 2013 5:13

    Published on: 19 November 2013

  3. Short report

    Anti-inflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: Hypertension blunts the response

    Exogenous administration of the anti-inflammatory cytokine, interleukin 10 (IL-10), is known to promote neuroprotection and mitigate neuroinflammation after ischemia. However, endogenous expression and localiz...

    Abdelrahman Y Fouda, Anna Kozak, Ahmed Alhusban, Jeffrey A Switzer and Susan C Fagan

    Experimental & Translational Stroke Medicine 2013 5:12

    Published on: 13 November 2013

  4. Research

    Coadministration of FTY720 and rt-PA in an experimental model of large hemispheric stroke–no influence on functional outcome and blood–brain barrier disruption

    Systemic thrombolysis with recombinant tissue plasminogen activator (rt-PA) is the standard of acute stroke care. Its potential to increase the risk of secondary intracerebral hemorrhage, especially if adminis...

    Aijia Cai, Frieder Schlunk, Ferdinand Bohmann, Sepide Kashefiolasl, Robert Brunkhorst, Christian Foerch and Waltraud Pfeilschifter

    Experimental & Translational Stroke Medicine 2013 5:11

    Published on: 28 October 2013

  5. Review

    An experimental protocol for in vivo imaging of neuronal structural plasticity with 2-photon microscopy in mice

    Structural plasticity with synapse formation and elimination is a key component of memory capacity and may be critical for functional recovery after brain injury. Here we describe in detail two surgical techni...

    Christian Stetter, Markus Hirschberg, Bernhard Nieswandt, Ralf-Ingo Ernestus, Manfred Heckmann and Anna-Leena Sirén

    Experimental & Translational Stroke Medicine 2013 5:9

    Published on: 10 July 2013

  6. Short report

    Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats

    Human cerebral small vessel disease (CSVD) has distinct histopathologic and imaging findings in its advanced stages. In spontaneously hypertensive stroke-prone rats (SHRSP), a well-established animal model of ...

    Stine Mencl, Cornelia Garz, Solveig Niklass, Holger Braun, Eva Göb, György Homola, Hans-Jochen Heinze, Klaus G Reymann, Christoph Kleinschnitz and Stefanie Schreiber

    Experimental & Translational Stroke Medicine 2013 5:8

    Published on: 25 June 2013

  7. Research

    Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients – an observational study

    To assess acute effects of bevacizumab (anti-VEGF therapy) on cerebral microvessels and systemic cardiovascular regulation.

    Manja Reimann, Gunnar Folprecht, Rocco Haase, Karolin Trautmann, Gerhard Ehninger, Heinz Reichmann, Focke Ziemssen and Tjalf Ziemssen

    Experimental & Translational Stroke Medicine 2013 5:7

    Published on: 13 May 2013

  8. Review

    Magnesium treatment for neuroprotection in ischemic diseases of the brain

    This article reviews experimental and clinical data on the use of magnesium as a neuroprotective agent in various conditions of cerebral ischemia. Whereas magnesium has shown neuroprotective properties in anim...

    Thomas Westermaier, Christian Stetter, Ekkehard Kunze, Nadine Willner, Furat Raslan, Giles H Vince and Ralf-Ingo Ernestus

    Experimental & Translational Stroke Medicine 2013 5:6

    Published on: 25 April 2013

  9. Research

    NAC changes the course of cerebral small vessel disease in SHRSP and reveals new insights for the meaning of stases - a randomized controlled study

    N-Acetylcystein (NAC) reduces the reperfusion injury and infarct size in experimental macroangiopathic stroke. Here we now investigate the impact of NAC on the development of the histopathology of microangiopa...

    Celine Zoe Bueche, Cornelia Garz, Siegfried Kropf, Daniel Bittner, Wenjie Li, Michael Goertler, Hans-Jochen Heinze, Klaus Reymann, Holger Braun and Stefanie Schreiber

    Experimental & Translational Stroke Medicine 2013 5:5

    Published on: 15 April 2013

  10. Review

    Blood brain barrier breakdown as the starting point of cerebral small vessel disease? - New insights from a rat model

    Cerebral small vessel disease (CSVD, cerebral microangiopathy) leads to dementia and stroke-like symptoms. Lacunes, white matter lesions (WML) and microbleeds are the main pathological correlates depicted in i...

    Stefanie Schreiber, Celine Zoe Bueche, Cornelia Garz and Holger Braun

    Experimental & Translational Stroke Medicine 2013 5:4

    Published on: 14 March 2013

  11. Research

    The combination of stem cell factor and granulocyte-colony stimulating factor for chronic stroke treatment in aged animals

    Stroke occurs more frequently in the elderly population and presents the number one leading cause of persistent disability worldwide. Lack of effective treatment to enhance brain repair and improve functional ...

    Chun-Shu Piao, Maria E Gonzalez-Toledo, Xi Gu and Li-Ru Zhao

    Experimental & Translational Stroke Medicine 2012 4:25

    Published on: 19 December 2012

  12. Short report

    Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia

    Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia. Howev...

    Jan-Sören Padberg, Matijs Van Meurs, Jan T Kielstein, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Jan G Zijlstra, Csaba P Kovesdy and Philipp Kümpers

    Experimental & Translational Stroke Medicine 2012 4:24

    Published on: 5 December 2012

  13. Research

    A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats

    Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerou...

    Furat Raslan, Christiane Albert-Weißenberger, Thomas Westermaier, Saker Saker, Christoph Kleinschnitz and Jin-Yul Lee

    Experimental & Translational Stroke Medicine 2012 4:23

    Published on: 29 November 2012

  14. Meeting report

    Report on the 4'th scientific meeting of the “Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie” (NEUROWIND e.V.) held in Motzen, Germany, Nov. 2’nd – Nov. 4’th, 2012

    From November 2nd - 4th 2012, the 4th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Again more than 60 participants, predominantly at the doctoral student or postdoc level, gathered to share th...

    Ralf A Linker, Sven G Meuth, Tim Magnus, Thomas Korn and Christoph Kleinschnitz

    Experimental & Translational Stroke Medicine 2012 4:22

    Published on: 22 November 2012

  15. Review

    Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

    Ischemic stroke is a leading cause of morbidity and mortality worldwide. Elevated plasma aldosterone levels are an independent cardiovascular risk factor and are thought to contribute to hypertension, a major ...

    Quynh N Dinh, Thiruma V Arumugam, Morag J Young, Grant R Drummond, Christopher G Sobey and Sophocles Chrissobolis

    Experimental & Translational Stroke Medicine 2012 4:21

    Published on: 30 October 2012

  16. Short report

    Isolation of inflammatory cells from rat brain tissue after stroke

    The pathophysiology of sterile inflammation following focal ischemic stroke is complex and not fully understood, but there is growing evidence that it offers several therapeutic options beyond the hitherto exi...

    Karoline Möller, Tobias Stahl, Johannes Boltze and Daniel-Christoph Wagner

    Experimental & Translational Stroke Medicine 2012 4:20

    Published on: 2 October 2012

  17. Research

    Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window

    Docosahexaenoic acid (DHA) complexed to human serum albumin (Alb) is neuroprotective after experimental stroke. Here we tested using lower concentrations of albumin as part of the complex to achieve neuroprote...

    Tiffany N Eady, Larissa Khoutorova, Kristal D Atkins, Nicolas G Bazan and Ludmila Belayev

    Experimental & Translational Stroke Medicine 2012 4:19

    Published on: 14 September 2012

  18. Research

    Thromboembolic stroke in C57BL/6 mice monitored by 9.4 T MRI using a 1H cryo probe

    A new thromboembolic animal model showed beneficial effects of t-PA with an infarct volume reduction of 36.8% in swiss mice. Because knock-out animal experiments for stroke frequently used C57BL76 mice we eval...

    Friederike L Langhauser, Patrick M Heiler, Saskia Grudzenski, Andreas Lemke, Angelika Alonso, Lothar R Schad, Michael G Hennerici, Stephen Meairs and Marc Fatar

    Experimental & Translational Stroke Medicine 2012 4:18

    Published on: 12 September 2012

  19. Research

    Impact of age on the efficacy of bone marrow mononuclear cell transplantation in experimental stroke

    Bone marrow-derived mononuclear cells (BM MNC) have been effectively used to treat experimental stroke. Most of the preclinical trials have been performed in young and healthy laboratory animals, even though a...

    Daniel-Christoph Wagner, Mitja Bojko, Myriam Peters, Marlene Lorenz, Cornelia Voigt, Alexander Kaminski, Dirk Hasenclever, Markus Scholz, Alexander Kranz, Gesa Weise and Johannes Boltze

    Experimental & Translational Stroke Medicine 2012 4:17

    Published on: 24 August 2012

  20. Research

    Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo

    Intracerebral administration of the angiotensin II type 2 receptor (AT2R) agonist, CGP42112, is neuroprotective in a rat model of ischemic stroke. To explore further its possible cellular target(s) and therapeuti...

    Seyoung Lee, Vanessa H Brait, Thiruma V Arumugam, Megan A Evans, Hyun Ah Kim, Robert E Widdop, Grant R Drummond, Christopher G Sobey and Emma S Jones

    Experimental & Translational Stroke Medicine 2012 4:16

    Published on: 24 August 2012

  21. Research

    Reduced infarct size in neuroglobin-null mice after experimental stroke in vivo

    Neuroglobin is considered to be a novel important pharmacological target in combating stroke and neurodegenerative disorders, although the mechanism by which this protection is accomplished remains an enigma. ...

    Zindy Raida, Christian Ansgar Hundahl, Jesper Kelsen, Jens Randel Nyengaard and Anders Hay-Schmidt

    Experimental & Translational Stroke Medicine 2012 4:15

    Published on: 20 August 2012

    The Erratum to this article has been published in Experimental & Translational Stroke Medicine 2013 5:10

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